Asymmetric total synthesis of the proposed structure of the medicinal alkaloid jamtine using the chiral base approach |
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Authors: | Simpkins Nigel S Gill Christopher D |
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Institution: | School of Chemistry, University of Nottingham, Nottingham, United Kingdom. nigel.simpkins@nottingham.ac.uk |
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Abstract: | reaction: see text] A highly step-economic asymmetric synthesis of the tetracyclic structure assigned to the medicinal alkaloid jamtine has been accomplished using a chiral lithium amide base desymmetrization of a ring-fused imide. The structure synthesized appears to be different from that of the natural product originally reported. |
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