Toward the synthesis of peloruside a: fragment synthesis and coupling studies |
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Authors: | Paterson Ian Di Francesco M Emilia Kühn Toralf |
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Institution: | University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, United Kingdom. ip100@cus.cam.ac.uk |
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Abstract: | reaction: see text] The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C(12)-C(19), C(7)-C(11), and C(1)-C(6) segments of peloruside A, is reported, along with boron-mediated aldol coupling studies directed toward the assembly of the complete carbon skeleton of this microtubule-stabilizing macrolide. |
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