Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation |
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| Authors: | Yan Siucheong Wong Iris L K Chow Larry M C Sun Hongzhe |
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| Institution: | Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. |
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| Abstract: | The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug. |
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