| 新型三氟甲基苯胺酰烷基三苯基季鏻盐的合成及其抗肿瘤活性 |
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| 引用本文： | 宋章凌,肖成林,张杰,娄兆文.新型三氟甲基苯胺酰烷基三苯基季鏻盐的合成及其抗肿瘤活性[J].合成化学,2011,19(6):759-761. |
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| 作者姓名： | 宋章凌 肖成林 张杰 娄兆文 |
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| 作者单位： | 湖北大学化学化工学院,湖北武汉,430062 |
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| 基金项目： | 湖北省自然科学基金资助项目(2008CDB039) |
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| 摘 要： | 以对或邻三氟甲基苯胺为原料,氯烷酰氯为连接基团,合成了4个新型的含酰胺结构的季鏻盐(3a～3d),其结构经1HNMR和IR表征.采取MTT法对3进行生物活性测试结果表明,部分季磷盐具有较高的抗肿瘤活性.
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| 关 键 词： | 季鏻盐 酰胺 合成 抗肿瘤活性 |
Synthesis and Anti-tumor Activities of Novel Triphenylphosphonium Containing Trifluoromethylphenylalkylamide |
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| SONG Zhang-ling,XIAO Cheng-lin,ZHANG Jie,LOU Zhao-wen.Synthesis and Anti-tumor Activities of Novel Triphenylphosphonium Containing Trifluoromethylphenylalkylamide[J].Chinese Journal of Synthetic Chemistry,2011,19(6):759-761. |
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| Authors: | SONG Zhang-ling XIAO Cheng-lin ZHANG Jie LOU Zhao-wen |
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| Institution: | SONG Zhang-ling,XIAO Cheng-lin,ZHANG Jie,LOU Zhao-wen(School of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062,China) |
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| Abstract: | Four novel triphenylphosphonium containing p-,or o-trifluoromethylphenylamide were synthesized from p-,or o-(trifluoromethyl)aniline using chloroalkyl chloride as the linking group.The structures were characterized by 1HNMR and IR.The biological activity test results showed that the some of them exhibited signification anticancer activity by MTT method. |
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| Keywords: | phosphonium acylamide synthesis anti-tumor activity |
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