Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats |
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| Authors: | Sridevi V K Chouhan Hemendra S Singh Narendra K Singh Sushil K |
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| Affiliation: | Department of Pharmaceutics , Institute of Technology, Banaras Hindu University, Varanasi-221005, India. |
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| Abstract: | This study was aimed at evaluating the antioxidant and hepatoprotective effects of the ethanol extract of Vitex glabrata (EEVG) in a CCl(4)-induced liver damage model in rats; and to isolate and characterise the bioactive constituent from EEVG. Hepatoprotective activity was evaluated by changes in the levels of the serum enzymes viz. AST, ALT, ALP and total bilirubin, and further by histopathological examinations of liver tissues. Antioxidant activity was measured in terms of superoxide dismutase, GSH, lipid peroxidation (LPO), catalase and peroxidase levels in liver homogenate. The pentamethoxy flavonoid artemetin was isolated and characterised from EEVG. Artemetin and EEVG pre-treatment significantly (p?
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