Primary and secondary kinetic isotope effects in E2 elimination reactions |
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| Authors: | Fouad M Fouad Patrick G Farrell |
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| Institution: | Max-Planck-Institut für Biochemie 8033 Martinsried bei München, W. Germany.;Department of Chemistry, McGill University 801 Sherbrook St. W., Montreal, Quebec, Canada. |
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| Abstract: | Primary and secondary deuterium kinetic isotope effects have been measured for elimination of LCl (L = H or D) from some substituted 1,2-diaryl-1-chloroethanes. Although changes in these effects are in agreement with theoretical predictions, the high values of (EH-ED)β and the significantly low AH/AD may suggest that either proton tunnelling or an internal return mechanism is complicating this E2 elimination. |
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