Three component, regioselective, one-pot synthesis of β-hydroxytriazoles from epoxides via ‘click reactions’ |
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| Authors: | J.S. Yadav B.V. Subba Reddy G. Madhusudhan Reddy D. Narasimha Chary |
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| Affiliation: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | 2-Azidoalcohols derived in situ from epoxides and sodium azide undergo smooth coupling with alkynes under neutral conditions by means of ‘click reactions’ to furnish β-hydroxytriazoles in excellent yields and with high regioselectivity. This reaction proceeds smoothly in water at room temperature without the need for acid catalysis. |
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| Keywords: | Epoxides 2-Azidoalcohols Alkynes Click reaction Triazoles |
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