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Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity |
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| Authors: | Jalpa C Trivedi Kuldip D Upadhyay Sudhir K Joshi Erik De Clercq |
| Institution: | a Department of Chemistry, Saurashtra University, Rajkot 360 005, India b Torrent Research Center, Gandhinagar 382 428, India c H & H. B. Kotak Institute of Science, Rajkot 360 005, India d Rega Institute for Medical Research, Katholieke Universiteit, Leuven B-3000, Belgium |
| Abstract: | Two closely structurally related coumarins, 4-hydroxy-8-isopropyl-5-methylcoumarin and 4-hydroxy-6-chloro-7-methylcoumarin were acylated at C-3 and further converted to the respective chalcones and two series of eighteen new compounds, which were evaluated for possible antiviral activity. |
| Keywords: | Antiviral Anti-HIV Chalcones 4-Hydroxycoumarins |
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