A novel synthetic route to 2-alkylpropane-1,3-sultones and its application to the synthesis of 2-alkyl derivatives of tramiprosate |
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Authors: | Benoit Bachand,Mohamed Atfani,Bita Samim,Sophie Lé vesque,Daniel Simard,Xianqi Kong |
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Affiliation: | Department of Chemistry, Neurochem Inc., 275, boul. Armand-Frappier, Laval, QC, Canada H7V 4A7 |
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Abstract: | A practical synthetic route to various 2-alkylpropane-1,3-sultones, the key intermediates for the preparation of 2-substituted homotaurines as analogs of tramiprosate, was developed. |
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Keywords: | Sultones Tramiprosate (3-amino-1-propanesulfonic acid) Alzheimer&rsquo s disease Amyloid β (Aβ) |
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