Multicomponent, solvent-free synthesis of β-aryl-β-mercapto ketones using zirconium chloride as a catalyst |
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Authors: | Atul Kumar Akanksha |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, UP, India |
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Abstract: | Zirconium chloride efficiently catalyzes the one-pot, three-component reaction of an aryl aldehyde, cyclic or acyclic enolizable ketones, and thiols under solvent-free conditions at room temperature to afford the corresponding β-aryl-β-mercaptoketones via aldol-Michael addition reactions. This methodology affords a large number of β-aryl-β-mercapto ketone derivatives in high yields and in short reaction times. |
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Keywords: | Zirconium chloride One-pot Multi-component reaction β-Aryl-β-mercapto ketones |
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