Diastereoselective synthesis of the polyol-containing side chain of the ent-bengamides |
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| Authors: | Ashley A Jaworski |
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| Institution: | Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, Canada H9H 3L1 |
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| Abstract: | The synthesis of the non-natural antipode of the bengamide polyol-containing side chain has been achieved utilizing a diastereoselective oxygenated-enolate aldol reaction as the key step. A substrate-controlled reduction was used to complete the stereochemical array. |
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| Keywords: | Bengamides Boron aldol reactions Substrate-controlled diastereoselectivity |
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