Zincate-type enolate for radical α-trifluoromethylation |
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| Authors: | Yuichi Tomita Yoshimitsu Itoh Koichi Mikami |
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| Affiliation: | a Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan
b Research Laboratory, TOSOH F-TECH Inc., 4988 Kaisei-cho, Shunan, Yamaguchi 746-0006, Japan |
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| Abstract: | Ketone zincate-type enolates can be applied to radical trifluoromethylation for the general synthesis of α-CF3-ketones, cyclopentanones in particular. The addition of diethylzinc to lithium enolates is the key in the preparation of the zincate-type enolates for efficient radical trifluoromethylation. |
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