Microwave assisted hydroaminomethylation of alkenes |
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| Authors: | Elena Petricci Jessica Salvadori |
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| Institution: | a Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy
b CNRS, Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7175/LC174, route du Rhin, BP 60024, F-67401 Illkirch Cedex, France |
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| Abstract: | Hydroaminomethylation of terminal alkenes can be regioselectively carried out in less than 30 min with secondary amines in EtOH under MW irradiation using (PPh3)3RhCO(H) and Xantphos or Biphephos as ligands. When primary amines were employed, the corresponding enamines were obtained in good yields. Tris-benzyl allylglycine was transformed into different (basic) benzylated α-amino acids. Moreover, the benzyl protection was removed in few minutes under MW irradiation with Pd(OH)2 under H2 atmosphere. |
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| Keywords: | Microwaves Hydroformylation Amine Amino acids Deprotection |
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