The Vilsmeier reagent as an efficient acid activator for the synthesis of β-lactams |
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| Authors: | Aliasghar Jarrahpour Maaroof Zarei |
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| Affiliation: | Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran |
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| Abstract: | The Vilsmeier reagent (chloromethylenedimethylammonium chloride) has been used as an efficient and cheap acid activator for the one-step Staudinger reaction of substituted acetic acids and imines under mild conditions. This reaction is clean and the by-products are DMF and triethylamine hydrochloride which were removed by simple aqueous work-up. |
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| Keywords: | Vilsmeier reagent β-Lactam Staudinger reaction Acid activator Cycloaddition reaction |
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