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Diversity oriented synthesis of benzoxazoles and benzothiazoles |
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| Authors: | Julia H. Spatz Thorsten Bach Julien Bardin Christoph Burdack |
| Affiliation: | a Priaton GmbH, Gmunder Strasse 37-37a, D-81739 München, Germany b Technical University Munich, Lichtenbergstrasse 4, D-85747 Garching, Germany |
| Abstract: | A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o-halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity. |
| Keywords: | Ugi-reaction Multi-component reaction Benzoxazoles Benzothiazoles Copper-catalyzed cyclization Cross-coupling |
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