Highly enantioselective cyclopropanation of trisubstituted olefins |
| |
| Authors: | Jun Li Long Zheng Hao Chen Lijia Wang Xiu-Li Sun Jun Zhu Yong Tang |
| |
| Affiliation: | 1.The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai,China;2.Collaborative Innovation Center of Chemical Science and Engineering,Tianjin,China |
| |
| Abstract: | A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl- and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo- and enantio-selectivity. |
| |
| Keywords: | |
| 本文献已被 CNKI SpringerLink 等数据库收录！ |
|
