Imaging of photodynamically generated singlet oxygen luminescence in vivo |
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| Authors: | Niedre Mark J Patterson Michael S Giles Anoja Wilson Brian C |
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| Institution: | Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto, Ontario, Canada. |
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| Abstract: | We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (1O21delta(g)]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit. |
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