Synthesis of isomeric, oxathiolone fused chalcones, and comparison of their activity toward various microorganisms and human cancer cells line |
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Authors: | Konieczny Marek Tadeusz Konieczny Wojciech Sabisz Michał Skladanowski Andrzej Wakieć Roland Augustynowicz-Kopeć Ewa Zwolska Zofia |
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Institution: | Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk, Poland. markon@amg.gda.pl |
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Abstract: | Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Proteus vulgaris, antifungal activity against Candida albicans, and tuberculostatic activity against Mycobacterium tuberculosis H(37)Rv and Mycobacterium kansasii strains. |
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