Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy |
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Authors: | Lefrancois Simon Fu Dan Holtom Gary R Kong Lingjie Wadsworth William J Schneider Patrick Herda Robert Zach Armin Sunney Xie X Wise Frank W |
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Institution: | Department of Applied Physics, Cornell University, Ithaca, New York 14853, USA. sl694@cornell.edu |
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Abstract: | We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from a Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal fiber to produce a synchronized two-color picosecond pulse train. We show that seeding the FWM process overcomes the deleterious effects of group-velocity mismatch and allows efficient conversion into narrow frequency bands. The source generates more than 160 mW of nearly transform-limited pulses tunable from 775 to 815 nm. High-quality coherent Raman images of animal tissues and cells acquired with this source are presented. |
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