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Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia |
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| Authors: | Xian-Fu WuYa-Dan Wang Shi-Shan Yu Nan JiangJing Ma Ren-Xiang TanYou-Cai Hu Jing Qu |
| Affiliation: | a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China b Key Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People’s Republic of China c State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People’s Republic of China |
| Abstract: | Four new acylphloroglucinols, lysidicins I and J (1 and 2), and lysidisides V and W (3 and 4), were isolated from the roots of Lysidice rhodostegia. Among them, compound 1 is a novel acylphloroglucinol, and compound 2 is the first naturally occurring acylphloroglucinol derivative with an uncommon spiro(benzofuran-[2H]pyran) skeleton. Their structures were elucidated by spectroscopic and chemical methods. The absolute configuration of 1 was assigned by employing dimolybdenum tetraacetate-induced CD spectrum method, and that of 2 was determined by analysis of their experimental and theoretically calculated CD spectra. Compounds 3 and 4 exhibited potent antioxidative activity with IC50 values of 3.29 and 3.39 μM, respectively. |
| Keywords: | Lysidice rhodostegia Acylphloroglucinols Structural elucidation ECD calculation Antioxidative activity |
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