A potential bone tumor therapeutic agent153Sm-EDTMP: Its synthesis and preliminary structure analysis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A potential bone tumor therapeutic agent153Sm-EDTMP: Its synthesis and preliminary structure analysis

Authors:	Sh Zh Luo M F Pu J Quao Zh L Liu Ch Y Zhang P J Zhao Y B Fu H F Deng

Institution:	(1) Southwest Institute of Nuclear Physics and Chemistry, P.O. Box 515-38, 610003 Chengdu, (P. R. China);(2) Department of Nuclear Medicine, West China University of Medical Sciences, 610041 Chengdu, (P. R. China)

Abstract:	Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for boné cancer in human beings. In this article, we present the results on synthesis and structure analysis of Samarium-153-EDTMP. In a basic medium,¹⁵³Sm-EDTMP can be readily prepared with a complexing yield not less than 98%, and it is confirmed that the ratio of the ligand to Sm is 11, and the charge of¹⁵³Sm-EDTMP is negative two.

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