Flow injection manifold for the direct spectrophotometric determination of bismuth in pharmaceutical products using Methylthymol Blue as a chromogenic reagent |
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Authors: | Themelis D G Tzanavaras P D Papadimitriou J K |
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Institution: | Department of Chemistry, Laboratory of Analytical Chemistry, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece. themelis@chem.auth.gr |
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Abstract: | A new simple and rapid flow injection method is reported for the direct determination of bismuth in pharmaceutical products. Methylthymol Blue (MTB) was used as a chromogenic reagent and the absorbance of the colored Bi(III)-MTB complex produced was monitored at 548 nm. The various chemical and physical variables were optimized and a study of interfering ions was also carried out. Linear calibration graphs were obtained from 0 to 100 mg l-1 Bi(m) (120 injections per hour). The precision was very good (sr = 1.3%) and the limit of detection was cL = 0.150 mg l-1. The average accuracy was also very good (er = 0.75%) and was evaluated by comparison of the results obtained with those claimed by the manufacturers. The method was found to be adequately selective, considering the ions that the samples contain. |
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