Ligand-Free Suzuki Coupling of Arylboronic Acids with Methyl (E)-4-Bromobut-2-enoate: Synthesis of Unconventional Cores of HIV-1 Protease Inhibitors |
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| Authors: | Lucia Chiummiento Maria Funicello Paolo Lupattelli Francesco Tramutola |
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| Institution: | Dipartimento di Chimica "Antonio Mario Tamburro", Università Degli Studi della Basilicata , Viale dell'Ateneo Lucano 10, 85100, Potenza, Italy. |
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| Abstract: | An effective ligand-free Suzuki coupling protocol to unite methyl (E)-4-bromobut-2-enoate with several arylboronic acids has been accomplished. Thus, a number of variously functionalized methyl 4-arylcrotonates have been achieved in high to excellent yields under mild conditions. This method enables the preparation of diverse aryl-substituted cores of HIV-1 protease inhibitors. |
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