Synthesis of Some Aminophosphonates Bearing N‐(Fluorophenyl)‐piperazynyl Moiety and Their Activity toward Serotonin Receptors |
| |
| Authors: | Andrzej Jóźwiak Paweł Tokarz Piotr M. Zagórski Róża Hamera Dariusz Cal Grzegorz Satała Andrzej J. Bojarski |
| |
| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of Łódź, 91‐403 Łódź, Poland;2. Department of Organic & Applied Chemistry, Faculty of Chemistry, University of Łódź, 91‐403 Łódź, Poland;3. Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, 31‐343 Kraków, Poland |
| |
| Abstract: | Syntheses of a series of compounds bearing a 1‐(fluorophenyl)piperazin‐4‐ylmethyl moiety, namely dialkyl 1‐(fluorophenyl)piperazin‐4‐ylmethyl phosphonates 3a–f , diethyl 2‐[1‐(fluorophenyl)piperazin‐4‐yl]‐ethyl phosphonates 4a,b , diethyl 3‐[1‐(4‐fluorophenyl)‐piperazin‐4‐yl]‐propyl phosphonate 5 , and di[1‐(fluorophenyl)piperazin‐4‐yl]methanes 6a,b were performed, and some of them were screened for their affinity for serotonin 5‐HT1A, 5‐HT6, and 5‐HT7 receptors. Moderate interactions with these receptors were demonstrated. |
| |
| Keywords: | |
|
|
