A novel formal total synthesis of cephalotaxine |
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Authors: | Li Wei-Dong Z Ma Bao-Chun |
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Affiliation: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liwd@lzu.edu.cn |
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Abstract: | A formal total synthesis of cephalotaxine (CET), the parent structure of antileukemia Cephalotaxus alkaloids, was achieved through a novel synthesis of the pentacyclic amino enone 4 by a rapid annulation of readily available beta-(3,4-methylenedioxy)phenethylamine (2), delta-valerolactone, and bromoacetone. |
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