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Synthesis,spectroscopic characterization,crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety
Authors:Sohail Saeed  Naghmana Rashid  Peter G Jones  Rizwan Hussain  Moazzam Hussain Bhatti
Institution:1.Department of Chemistry, Research Complex,Allama Iqbal Open University,Islamabad,Pakistan;2.Institut für Anorganische und Analytische Chemie,Technische Universit?t Braunschweig,Braunschweig,Germany;3.National Engineering & Scientific Commission,Islamabad,Pakistan
Abstract:
Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P21/n with unit cell dimensions a = 11.7752(6) Å, b= 3.8677(2) Å, c= 27.4126(13) Å and β = 92.734(5) Å. There is a strong intramolecular hydrogen bond of the type N-H?O, with H?O distance of 2.5869(19) Å. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity.
Keywords:
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