Design, synthesis and anti-proliferative studies of a novel series of indirubin derivatives |
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| Authors: | Tian Cai Wang Ju Zhi Wei Chuan Sheng Guo Hui Bin Zhang Hou Xing Fan |
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| Affiliation: | a Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;b Shanghai Sun-sail Pharmaceutical Science & Technology Co., Ltd., Shanghai 201203, China |
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| Abstract: | A series of novel derivatives of indirubin were synthesized and evaluated for their anti-proliferative activity against human cancer cell lines of SGC7901, A549, HL-60, SK-BR-3 and HCT116. Most of the compounds displayed more potent activity than Sunitinib. In addition, the derivatives showed improved water solubility, which may be favorable to their pharmacokinetic performances. |
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| Keywords: | Anti-proliferative activity Indirubin Sunitinib |
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