Synthesis,crystal structures,DNA binding and oxidative cleavage studies of copper(II) complexes of N2S2 tetradentate ligands |
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| Authors: | Si-Ping Tang Lei Hou Zong-Wan Mao Liang-Nian Ji |
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| Affiliation: | 1. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China;2. Department of Chemistry and Material Science Hengyang Normal University, Hengyang Hunan 421008, China |
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| Abstract: | Two new copper(II) complexes with aminothioether ligands, [Cu(L1)(ClO4)](ClO4) · 0.5H2O (1) and [Cu(L2)(H2O)](ClO4)2 · H2O (2) (L1 = 2-benzyl-1,3-bis(aminoethylthio)propane and L2 = 2-(4-butylbenzyl)-1,3-bis(aminoethylthio)propane), have been synthesized and characterized. The single crystal X-ray diffraction analysis reveals that both 1 and 2 adopt distorted square pyramidal geometries. The binding modes of both complexes with calf thymus DNA were investigated by UV–Vis and CD spectroscopies. The results show that both complexes mainly adopt an electrostatic attraction binding mode with DNA and the binding constants are (1.62 ± 0.02) × 103 and (2.02 ± 0.02) × 103 M−1, respectively. Both complexes are able to cleave pBR322 plasmid DNA efficiently in the presence of ascorbic acid and the activity of 2 is higher than that of 1. The DNA cleavage by 1 and 2 were inhibited strongly in the presence of DMSO and tert-butyl alcohol, which suggests that hydroxyl radicals are the reactive oxygen species for the cleavage. |
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| Keywords: | Copper(II) complex Aminothioether ligand Crystal structure DNA binding Nuclease activity |
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