Synthesis and structural characterization of novel neutral fac-M(CO)3(NSO) complexes (M = Re,Tc) with N-acetylcysteine derivatives as tridentate NSO ligands |
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| Authors: | O. Karagiorgou D. Papagiannopoulou P. Kyprianidou G. Patsis A. Panagiotopoulou C. Tsoukalas C.P. Raptopoulou M. Pelecanou I. Pirmettis M. Papadopoulos |
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| Affiliation: | 1. Institute of Radioisotopes-Radiodiagnostic Products, National Centre for Scientific Research “Demokritos”, 15310 Ag. Paraskevi, Athens, Greece;2. Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;3. Institute of Biology, National Centre for Scientific Research “Demokritos”, 15310 Ag. Paraskevi, Athens, Greece;4. Institute of Materials Science, National Centre for Scientific Research “Demokritos”, 15310 Ag. Paraskevi, Athens, Greece |
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| Abstract: | The reaction of [NEt4]2[Re(CO)3Br3] with equimolar amount of a tridentate NSO ligand in methanol leads to the formation of neutral tricarbonyl rhenium(I) complexes of the general formula Re(CO)3(NSO), where the NSO ligand is o-C5H4N-CH2CH2-S-CH2CH(NHCOCH3)COOH (L1H), complex 1 or o-C5H4N-CH2CH2-S-C(CH3)2CH(NHCOCH3)COOH (L2H), complex 2. Both complexes have been characterized by elemental analysis and spectroscopic methods, while complex 2 has also been characterized by X-rays analysis. At technetium-99m level, the corresponding fac-[99mTc(CO)3(NSO)] complexes 3 and 4, were obtained in high yield by reacting ligands L1H or L2H with the fac-[99mTc(CO)3(H2O)3]+ precursor in water. Their structure was established by chromatographic comparison to the prototype rhenium complex using high-performance liquid chromatographic techniques. |
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| Keywords: | Technetium-99m Rhenium Carbonyls Cysteine |
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