| Isolation and Characterization of an Antimicrobial Polypeptide from Loach |
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| 引用本文： | Xian Zhi DONG,Hui Bi XU*,Kai Xun HUANG,Qiong LIU Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074. Isolation and Characterization of an Antimicrobial Polypeptide from Loach[J]. 中国化学快报, 2003, 0(1) |
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| 作者姓名： | Xian Zhi DONG Hui Bi XU* Kai Xun HUANG Qiong LIU Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 |
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| 作者单位： | Xian Zhi DONG，Hui Bi XU*，Kai Xun HUANG，Qiong LIU Department of Chemistry，Huazhong University of Science and Technology，Wuhan 430074 |
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| 摘 要： | Hydrobionts formed their special defense systems during evolution. One such system is that of non-specific immunity which comprises a wide variety of peptides with potent antimicrobial activities1. The mechanism of action of most antimicrobial peptides was reported as that a few peptide molecules formed a channel on cell membrane, and the cell was then died of the outflowing of cellular contents. The above mechanism was different from that of antibiotics2, 3. It is a promising area to disc…
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Isolation and Characterization of an Antimicrobial Polypeptide from Loach |
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| Xian Zhi DONG,Hui Bi XU,Kai Xun HUANG,Qiong LIU. Isolation and Characterization of an Antimicrobial Polypeptide from Loach[J]. Chinese Chemical Letters, 2003, 0(1) |
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| Authors: | Xian Zhi DONG Hui Bi XU Kai Xun HUANG Qiong LIU |
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| Affiliation: | Xian Zhi DONG,Hui Bi XU*,Kai Xun HUANG,Qiong LIU Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074 |
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| Abstract: | A novel antimicrobial polypeptide was isolated and characterized from loach, Misgurnus anguillicaudatus. The polypeptide, named MAPP, is a single-chain polypeptide with Mw about 9,800 Dalton and pI about 4.78; the N-tag of MAPP was CFGWN. MAPP showed good inhibition against various bacteria including Bacillus subtilis, Escherichia coli and Staphylococcus aureus. MAPP could be used as a lead compound in antibiotics drug discovery. |
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| Keywords: | Misgurnus anguillicaudatus isolation characterization. |
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