Evaporative light scattering detection: trends in its analytical uses |
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Authors: | R Lucena S Cárdenas M Valcárcel |
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Institution: | (1) Department of Analytical Chemistry, Marie Curie Building (Annex), Campus de Rabanales, University of Córdoba, 14071 Cordoba, Spain |
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Abstract: | Evaporative light scattering detection (ELSD) is widely recognized as a universal tool for liquid and supercritical chromatographies.
In addition, this detection technique is fully compatible with continuous-flow systems. In fact, the combination of continuous
non-chromatographic techniques and ELSD affords the design of simple, reliable systems for extracting qualitative information.
This paper reviews instrumental innovations regarding the miniaturization of evaporative light scattering detectors and their
uses in micro and capillary liquid chromatography; also, it discusses their increasingly important role in the development
of vanguard configurations for sample screening and the determination of total indices without the need for chromatographic
separation. Moreover, it compares them with other types of chromatographic detectors in terms of performance. Finally, the
potential of ELSD for solving real-life analytical problems arising from the need to meet (bio)chemical information needs
is illustrated with various selected applications.
Figure New trends in evaporative light scattering detection: recent chromatographic uses and its role in vanguard/rearguard strategies |
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Keywords: | Evaporative light scattering detection Universal detectors Liquid chromatography Total indices Vanguard/rearguard analytical strategies |
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