Synthesis of an advanced intermediate en route to the mitomycin natural products |
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| Authors: | Williams Amie L Srinivasan Jayasree M Johnston Jeffrey N |
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| Affiliation: | Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235-1822, USA. |
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| Abstract: | [Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation. |
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