Properties of L-phenylalanine tetraamides as chiral selectors for D,L-amino acids by capillary gas chromatography

Summary A wide series of L-phenylalanine tetraamide selectors (Phe-n-O-TA) have been synthesized and used as stationary phases for chiral resolution of D,L-amino acids by capillary gas chromatography. The influence of length and polarity of the oxaalkanoyl bridge spacing the diamide chains of the selectors and the effects of steric hindrance on separating power were investigated. The characteristics of the chiral columns and the separation factors of D,L-n-butyl-N-trifluoroacetyl amino esters are reported.