Studies on Curcumin Loaded Poly(N-isopropylacrylamide) Silver Nanocomposite Hydrogels for Antibacterial and Drug Releasing Applications |
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| Authors: | Sakey Ravindra Kokkarachedu Varaprasad V Rajinikanth Antoine F Mulaba-Bafubiandi Koduri Venkata Surya Ramam |
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| Institution: | 1. Department of Chemical Engineering Technology, Faculty of Engineering and the Built Environment , University of Johannesburg , Johannesburg , South Africa;2. Departamento de Ingeniería de Materiales-DIMAT , Facultad de Ingeniería Universidad de Concepción , Concepción , Chile;3. Department of Metallurgy, Faculty of Engineering and the Built Environment , University of Johannesburg , Johannesburg - 2028 , South Africa |
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| Abstract: | Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications. |
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| Keywords: | Silver nanocomposites curcumin hydrogels antibacterial activity |
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