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Design and Synthesis of Novel Pegylated 4‐Methylcoumarins |
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| Authors: | Mukesh K Pandey Rahul Tyagi Shilpi Tomar Jayant Kumar Virinder S Parmar |
| Affiliation: | 1. Institute of Nano‐Science and Engineering Technology, University of Massachusetts Lowell , MA;2. Center for Advanced Material, University of Massachusetts Lowell , MA;3. Bio‐organic laboratory, Department of Chemistry , University of Delhi , Delhi , India;4. Bio‐organic laboratory, Department of Chemistry , University of Delhi , Delhi , India |
| Abstract: | Coumarins are well known for their antioxidant and anti‐edema activities. Their antioxidant property gets enhanced with a methyl group at the C‐4 position of the pyran ring. To increase the antioxidant potential and their hydrophilicity, a lipase (Novozyme 435) catalyzed copolymerization of 4‐methylcoumarin diesters and polyethylene glycols (PEGs) has been carried out to give novel copolymers. |
| Keywords: | 4‐methylcoumarin PEG antioxidant lipase |