Synthesis of Cationic Dumbbell-shaped Fullerene Nanostructures as Potential Photodynamic Sensitizers |
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| Authors: | Sammaiah Thota Seaho Jeon Min Wang Long Y Chiang |
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| Institution: | Department of Chemistry, Institute of Nanoscience and Technology , University of Massachusetts Lowell , Lowell, Massachusetts |
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| Abstract: | A design of novel hydrophilic tetracationic dumbbell-shaped 60]fullerene nanostructures was made by balancing the hydrophilicity and hydrophobicity characteristics of the fullerene adduct for their potential application as photodynamic sensitizers in the PDT treatment. A sequential protection-deprotection reaction pathway was applied for the functional differentiation between primary and secondary amine moieties of pentaethylene hexamine. Synthesis of the target molecule involves two key steps of unsymmetrical esterification and amidation of malonic acid and subsequent fullerenation. The synthetic strategy was accomplished using mild reaction conditions in the intermediate molecule preparation and led a moderate overall product yield. |
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| Keywords: | Tetracationic fullerene derivatives dumbbell-shaped nanostructures photosensitizer photodynamic therapy amphiphilic fullerenes |
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