Preparation of Biomimetic Zwitterionic Core Cross-Linked Nanocarriers for Control Release of Bioactive Agents |
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| Authors: | Xiaohong Wang Guohua Jiang Yin Wang Rijing Wang Xinke Sun Ruanbing Hu |
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| Affiliation: | 1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education , Zhejiang Sci-Tech University , Hangzhou , P. R. China;2. Department of Materials Engineering, College of Materials and Textile , Zhejiang Sci-Tech University , Hangzhou , P. R. China |
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| Abstract: | Biomimetic core cross-linked nanocarriers (CCL-NCs) with zwitterionic shell was constructed from an amphiphilic block copolymer poly(2-(dimethylamino) ethyl methacrylate-co-carboxybetaine)-b-polystyrene ((PDMAEMA-co-PCB)-b-PS) via mini-emulsion RAFT polymerization. CCL-NCs present in this report possess properties of redox-sensitivity, limited unspecific protein adsorptions and low cytotoxicity, which highly enhance their potential application in drug delivery. Morphology of CCL-NCs was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. The control release process has also been investigated under three different conditions with or without dithiothreitol (DTT) at pH 5.4, 6.5 and 7.4. |
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| Keywords: | Biomimetic core cross-linked nanocarriers controlled release drug delivery |
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