Preparation of Epoxy-Functionalized Magnetic Polymer Nanospheres for Magnetically Targeted Radiotherapy |
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| Authors: | Xiaojuan Zhang Huijuan Sun Xiaoyu Chen Wei Jiang Jimin Wu |
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| Affiliation: | 1. School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China;2. Wujiang Science and Technology Bureau, Suzhou 215000, China;3. National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing 210094, China |
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| Abstract: | Magnetic poly(styrene?methyl methacrylate-glycidyl methacrylate)/Fe3O4 nanospheres with epoxy groups were prepared by modified one-step mini-emulsion polymerization in the presence of Fe3O4 ferrofluids. The products were characterized by fourier-transform infrared spectrum, transmission electron microscopy, thermogravimetric analysis and vibrating sample magnetometer. After surface modification with diaminopropane, histidine was covalently linked to the amine group of magentic nanospheres using glutaraldehyde as crosslinker. Finally, the preliminary labeling study based on non-radioactive rhenium was carried out and the labeling efficiency reached 80.4%. Such magnetic nanospheres had promising potential in magnetically targeted radiotherapy of cancer. |
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| Keywords: | Magnetic polymer nanospheres epoxy-functionalized mini-emulsion polymerization labeling non-radioactive rhenium |
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