Novel Carboxymethyl Chitosan Microspheres for Controlled Delivery of Chelerythrine |
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| Authors: | Gui-Yin Li Ming Zhong Zhi-De Zhou Ping Ding Yuan-Jian Li |
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| Affiliation: | 1. School of Life and Environmental Sciences , Guilin University of Electronic Technology , Guilin, Guangxi, China;2. School of Chemistry and Chemical Engineering , Hunan Institute of Science and Technology , Yueyang, Hunan, China;3. School of Public Health , Central South University , Changsha, Hunan, China;4. Department of Pharmacology, School of Pharmaceutical Sciences , Central South University , Changsha, Hunan, China;5. Department of Pharmacology, School of Pharmaceutical Sciences , Central South University , Changsha, Hunan, 410078, China Phone: +86–731-84805462 Fax: +86–731-84805462 |
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| Abstract: | Novel carboxymethyl chitosan (O-CMCS) microspheres containing an anti-tumor drug chelerythrine (CHE) have been successfully prepared by an emulsion crosslinking method using glutaraldehyde. The optimized microsphere formulation was characterized for particle size, shape, morphology, crystallinity and in vitro drug release. Results for mean particle size, drug loading content, entrapment efficiency and in vitro drug release of chelerythrine loaded microspheres were found to be 12.18 μm, 4.08%, 54.78% and 35.30% at pH 7.4 in 20 h, respectively. The optimized microspheres had an imperfect crystalline lattice and a spherical, rough morphology and the CHE release from O-CMCS microspheres followed the Higuchi matrix model. All these results suggested that O-CMCS microspheres are a promising carrier system for controlled drug delivery. |
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| Keywords: | O-carboxymethylchitosan chelerythrine drug delivery controlled release |
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