Amino Acid and Poly(Ethylene Glycol) Based Self-Organizing Polymeric Systems: Chemo-Enzymatic Synthesis and Characterization |
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| Authors: | Rahul Tyagi Rajesh Kumar Mukesh K Pandey Jayant Kumar Virinder S Parmar Arthur C Watterson |
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| Institution: | 1. Institute of Nano-Science and Engineering Technology , University of Massachusetts Lowell , Lowell, MA;2. Center for Advanced Materials , University of Massachusetts Lowell , Lowell, MA;3. Bio-Organic Laboratory, Department of Chemistry , University of Delhi , Delhi, India |
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| Abstract: | A chemo/regio selective enzymatic methodology has been designed to synthesize amphiphilic copolymers based on amino acid diesters and poly(ethylene glycol) PEG]. The condensation polymerization was catalyzed by immobilized Candida antarctica lipase B (Novozyme 435) under solvent-less conditions. The synthesized polymers 3a–c were derivatized with long chain acid chlorides by chemical acylation to get the amphiphilic polymers 4a–c. The physical properties of the synthesized amphiphilic polymers viz: aggregation number, critical micelle concentration (CMC), radius of gyration (Rg), hydrodynamic radius (Rh) and particle size distribution were studied by static and dynamic light scattering (SLS and DLS) techniques. The polymers were found to be promising in drug delivery applications. |
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| Keywords: | Amphiphilic copolymer Novozyme-435 Candida antarctica lipase micelle chemo/regioselectivity |
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