Direct arylation of imidazo[1,2-a]pyridine at C-3 with aryl iodides, bromides, and triflates via copper(I)-catalyzed C-H bond functionalization |
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| Authors: | Cao Hua Zhan Haiying Lin Yuanguang Lin Xiulian Du Zuodong Jiang Huanfeng |
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| Institution: | School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China. hua.cao@mail.scut.edu.cn |
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| Abstract: | A convenient method for the copper(I)-catalyzed arylation of substituted imidazo1,2-a]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo1,2-a]pyridine by Cu(I) catalysis to construct various functionalized imidazo1,2-a]pyridine core π-systems. |
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