Polystyrene-supported (2S)-(-)-3-exo-piperazinoisoborneol: an efficient catalyst for the batch and continuous flow production of enantiopure alcohols |
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| Authors: | Osorio-Planes Laura Rodríguez-Escrich Carles Pericàs Miquel A |
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| Institution: | Institute of Chemical Research of Catalonia, Av. Pa?sos Catalans, 16, E-43007 Tarragona, Spain. |
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| Abstract: | A polystyrene-supported analog (PS-PIB) of 3-exo-morpholinoisoborneol (MIB), designed for increased chemical stability, has been synthesized and used as a ligand in the asymmetric alkylation of aldehydes with Et(2)Zn. The supported ligand turned out to be highly active and enantioselective for a broad scope of substrates (92-99% ee), allowing repeated recycling. A single-pass, continuous flow process implemented with PS-PIB shows only a marginal decrease in conversion after 30 h of operation. |
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