Formal nucleophilic substitution of bromocyclopropanes with azoles |
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| Authors: | Ryabchuk Pavel Rubina Marina Xu Jack Rubin Michael |
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| Institution: | Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA. |
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| Abstract: | A highly diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with azoles is described. A wide range of azoles, including pyrroles, indoles, benzimidazoles, pyrazoles, and benzotriazoles, can be efficiently employed as pronucleophiles in this transformation, providing expeditious access to N-cyclopropyl heterocycles. |
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