An efficient synthesis of oosporein |
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| Authors: | Brian E. Love Jeffrey Bonner-Stewart |
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| Affiliation: | a Department of Chemistry, East Carolina University, Greenville, NC, 27858, USA
b PhytoMyco Research Corporation, 1800 N. Greene St., Suite H, Greenville, NC 27834, USA |
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| Abstract: | Fungal metabolite oosporein was prepared in four steps and 24% overall yield starting from 2,5-dimethoxytoluene. It was demonstrated that treatment of phoenicin with pyrrolidine and copper(II) acetate led to oosporein, whereas similar treatment of the isomeric ‘isophoenicin’ produced a benzofuran diquinone. No chromatography was required during any step of the synthesis. |
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| Keywords: | Oosporein Total synthesis Diquinone Thiele-Winter acetoxylation |
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