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Cassaine diterpenoid dimers isolated from Erythrophleum succirubrum with TRAIL-resistance overcoming activity |
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| Authors: | Takashi Miyagawa Takashi Koyano Masami Ishibashi |
| Affiliation: | a Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan b Temko Corporation, 4-27-4 Honcho, Nakano, Tokyo 164-0012, Japan c Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand |
| Abstract: | Activity-guided fractionation of Erythrophleum succirubrum for TRAIL resistance-overcoming activity led to the isolation of four new cassaine diterpenoid dimers, named erythrophlesins A-D (1-4). Their structures were elucidated by spectral data to show that they have an unsymmetrical dimeric structure through an ester bond between two cassaine diterpenoids. These new compounds were revealed to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma (AGS) cells. |
| Keywords: | Diterpenoid dimer Erythrophleum succirubrum TRAIL-resistance overcoming activity Cassaine |
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