Radical-initiated cyclization as a key step for the synthesis of oxoprotoberberine alkaloids期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Radical-initiated cyclization as a key step for the synthesis of oxoprotoberberine alkaloids

Authors:	Chih-Shone Lee Tsung-Ching Yu Yen-Yao Cheng

Institution:	^a Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, ROC ^b Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan, ROC

Abstract:	The oxoprotoberberine alkaloids 1a-d have been synthesized efficiently from the enamide derivatives 2a-d by a radical-initiated cyclization reaction utilizing n-Bu₃SnH/AIBN and CuCl. The enamide derivatives 2a-d were prepared from phenylethylamine analogues 5a-b, followed by acylation with acetic anhydride, Bischler-Napieralski cyclization with POCl₃ and benzoylation with the corresponding bromobenzoyl chloride, respectively.

Keywords:	Alkaloids Oxoprotoberberine Radical-initiated cyclization
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