A chemoenzymatic asymmetric synthesis of (9S,12S,13S)- and (9S,12RS,13S)-pinellic acids |
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Authors: | Anubha Sharma Seema Mahato Subrata Chattopadhyay |
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Institution: | Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India |
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Abstract: | A brief and facile synthesis of the title compounds has been developed by using an efficient lipase-catalyzed acylation and a chiral template-directed diastereoselective alkylation for incorporating the stereogenic centres. A cross-metathesis was employed to get the required E-olefin geometry. |
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