Methyl 2-methoxytetrafluoropropionate as a synthetic equivalent of methyl trifluoropyruvate in the Claisen condensation. The first synthesis of 2-(trifluoroacetyl)chromones and 5-aryl-2-hydroxy-2-(trifluoromethyl)furan-3(2H)-ones |
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| Authors: | Roman A. Irgashev,Nataliya Kalinovich,Gerd-Volker Rö schenthaler |
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| Affiliation: | a Department of Chemistry, Ural State University, pr. Lenina 51, 620083 Ekaterinburg, Russian Federation
b Institute of Inorganic and Physical Chemistry, University of Bremen, 28334 Bremen, Germany |
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| Abstract: | 2-(Trifluoroacetyl)chromones and 5-aryl-2-hydroxy-2-(trifluoromethyl)furan-3(2H)-ones were obtained in good yields via the Claisen condensation of acetophenones with methyl 2-methoxytetrafluoropropionate, followed by sulfuric acid-mediated deprotection of the reaction products. |
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| Keywords: | Methyl 2-methoxytetrafluoropropionate Acetophenones Claisen condensation Deprotection Trifluoromethyl 1,2,4-triketones |
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