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Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes |
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| Authors: | Xavier Companyó ,Martin Kamlar,Albert Moyano,Ramon Rios |
| Affiliation: | a Departament de Química Orgànica, Universitat de Barcelona, Facultat de Química, C. Martí i Franquès 1-11, 08028 Barcelona, Catalonia, Spain b Department of Organic Chemistry, Charles University, Hlavova 2030, 128 00 Prague, Czech Republic c Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08018-Barcelona, Castalonia, Spain |
| Abstract: | A highly enantioselective organocatalytic fluoromalonate addition to α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities. |
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