Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections |
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Authors: | Markus Stoeckli Dieter Staab Alain Schweitzer |
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Affiliation: | aNovartis Institutes of BioMedical Research, Analytical & Imaging Sciences, WSJ-503.1101, Lichtstrasse 35, 4002 Basel, Switzerland;bExploratory Development, Drug Metabolism and Pharmacokinetics, Novartis, Basel, Switzerland |
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Abstract: | The determination of the compound distribution in laboratory animal tissue in early development is a standard process in pharmaceutical research. While this information is traditionally obtained by means of whole-body autoradiography using radiolabeled compounds, this technology does not distinguish between metabolites and parent compound. The technique described in this article, termed matrix-assisted laser desorption/ionization (MALDI) mass spectrometric imaging, can fill this gap by simultaneously measuring compound and multiple metabolites distributed in whole-body tissue sections, using non-labeled compounds. |
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Keywords: | Mass spectrometry MALDI Drug Imaging Metabolites |
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